|
KMID : 0616120160470010049
|
|
Korean Journal of Pharmacognosy
2016 Volume.47 No. 1 p.49 ~ p.54
|
|
|
Cardiovascular Protective Effects of the n-Butanol Fraction from Glehnia littoralis Fr. Schm. in a High-Fat-Diet Mouse Model and Its Composition
|
|
LIM Hyun-Jin
Kwon Han-Sol
Cho Hyun-Woo
An Byeong-Kwan
Cho Jung-Hee
Oak Min-Ho
Kim Hyun-Jung
Han Dong-Sul
|
|
|
Abstract
|
|
|
|
In our search for natural products affecting blood circulation, the n-butanol fraction from whole plant of Glehnia littoralis Fr. Schm. (GLB) improved blood lipid parameters, and ameliorated obesity in high-fat-diet (HFD)-fed C57BL/6 mouse model. Hyperlipidemia was induced by high-fat-diet for 4 weeks, and then GLB was orally administrated with 400 mg/kg/day for 4 weeks. GLB-treated group showed that the gain in body weight was significantly attenuated, the levels of total cholesterol and triglyceride significantly lowered on blood chemical analysis, and significantly prolonged the mice bleeding time when compared with those of HFD control group. Concomitantly, phytochemical composition of GLB was investigated by HPLC-hyphenated spectroscopy, and two major phenolic compounds, rutin and chlorogenic acid were identified in the GLB. Taken together, these results indicate that GLB has cardiovascular protective effects and could be a natural medicine candidate for the prevention of cardiovascular disease.
|
|
|
KEYWORD
|
|
|
Glehnia littoralis Fr. Schm. , High-fat-diet mouse model , Cardiovascular protection
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|